Great Plains Tribal Leaders Health Board (GPTLHB), formerly the Great Plains Tribal Chairmen’s Health Board, was awarded the SAMHSA Tribal Opioid Response Grant. The program supplements current activities focused on reducing the impact of opioids and will contribute to a comprehensive response to the opioid epidemic. The program aims to address the opioid crisis in tribal communities by increasing access to culturally appropriate and evidence-based treatment, including medication-assisted treatment (MAT) using one of the three FDA-approved medications to treat opioid use disorder (OUD). In addition to focusing on OUD, recipients may also address stimulant misuse and use conditions, including cocaine and methamphetamine. The intent is to reduce unmet treatment need and opioid overdose-related deaths by providing prevention, treatment, and recovery support services for OUD and, if so desired, stimulant misuse and use disorders. The communities that the GPTLHB has partnered with are the Crow Creek Sioux Tribe and the American Indian community of the He Sapa (Pennington County, South Dakota).